miR-128: Pleiotropic Player in Cardiac Development
نویسندگان
چکیده
منابع مشابه
miR-21: a star player in cardiac hypertrophy.
MicroRNAs (miRNAs), small non-coding RNA molecules, are derived from intergenic, intronic, or exonic regions in the genome and are transcribed by RNA polymerases into primary transcripts (pri-miRNAs) as single genes or clusters. Pri-miRNAs, which contain stem-loop structures harbouring the miRNAs in the 5′ or 3′ half of the stem, are recognized by the endonuclease Drosha in the nucleus to produ...
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The present study aimed to investigate the role and mechanism of micro RNA (miR)-128 in hypertension-induced myocardial injury. The peripheral blood of patients with hypertension was collected and the expression of miR-128 was detected using fluorescence reverse transcription-quantitative polymerase chain reaction (RT-qPCR). Primary myocardial cells isolated from rat in vitro were cultured unde...
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MicroRNAs are a class of small noncoding RNAs that function as critical gene regulators through targeting mRNAs for translational repression or degradation. In this study, we showed that miR-128 expression levels were decreased in glioma, and identified p70S6K1 as a novel direct target of miR-128. Overexpression of miR-128 suppressed p70S6K1 and its downstream signaling molecules such as HIF-1 ...
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Telomerase is a unique cellular reverse transcriptase (RT) essential for maintaining telomere stability and required for the unlimited proliferation of cancer cells. The limiting determinant of telomerase activity is the catalytic component TERT, and TERT expression is closely correlated with telomerase activity and cancer initiation and disease progression. For this reason the regulation of TE...
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ژورنال
عنوان ژورنال: The Thoracic and Cardiovascular Surgeon
سال: 2018
ISSN: 0171-6425,1439-1902
DOI: 10.1055/s-0038-1628041